Wide range of sizes available


The Dohmeyer Lab Cryogenic Pelletizer is engineered for testing, laboratory research, and pilot-scale formulation ofhigh-value liquid products. The unit utilizes a peristaltic pump to dispense liquid formulations through interchangeable dripping nozzles. Dohmeyer supplies interchangeable nozzles, allowing process engineers to adjust dosing parameters to product viscosity and achieve precise target pellet dimensions.
During operation, liquid droplets drop into a bath of liquid nitrogen, where extreme thermal transfer causes instant contact freezing. This rapid cooling solidifies the droplets into free-flowing spherical pearls that drop below
–40°C within seconds, yielding a consistent pellet size distribution between 3mm and 5mm.
The instant thermal shock prevents satellite droplet formation and protects the tertiary and quaternary structures of fragile enzymes, while preserving high cell viability in starter cultures (Lactobacillus, Bifidobacterium) and ferments.
Because cold energy is transferred directly to the droplets rather than a bulk liquid volume, the lab system operates with low liquid nitrogen consumption, providing a compact footprint and simple cleaning protocols between test runs.


The Batch (or Barrel) Cryogenic Pelletizer provides a flexible, campaign-based solution capable of processing up to 50 kg per batch. Designed for intermediate production volumes, trial manufacturing, and specialized active ingredients, the system uses customized dispenser manifolds and dripping nozzles matched to the specific rheology and viscosity of the product.
A core technical feature of the batch system is the controlled injection of gaseous nitrogen, which creates a defined liquid circulation within the bath to regulate product retention time. As liquid droplets freeze instantly upon contact with liquid nitrogen, the solidcryo-pellets sink and collect inside an internal retrieval basket located at the bottom of the vessel. Once a batch is completed, product harvesting is performed by lifting the basket out using an overhead crane, or by pivoting/rotating the pelletizer vessel to discharge the pellets into storage containers. This closed barrel configuration ensures complete product recovery without cross-contamination, making it well-suited for validated biopharmaceutical and probiotic production campaigns.
For 24/7 commercial manufacturing, Dohmeyer’s Continuous Cryogenic Pelletizer delivers scalable throughputs ranging from 50kg up to 850 kg per hour. Liquid product is metered continuously through custom multi-nozzle arrays into a liquid nitrogen immersion trough. The resulting frozen pellets are continuously evacuated from the cryogen bath via a heavy-duty SS316 stainless steel mesh conveyor belt.
The machine incorporates an integrated exhaust fan system that safely extracts excess vaporized nitrogen gas from the process chamber. For stringent hygiene compliance, the unit includes a fully automated Clean-In-Place (CIP) system equipped with SS316 rigid piping, multi-circuitcontrol valves, and strategically positioned spray headers.
System operation, temperature control, and CIP/sterilization routines are managed via a Dohmeyer control system with a HMI touch visualization interface.


The modern processing landscape requires equipment capable of adapting to diverse product portfolios, from biopharma suspensions to consumer ice treats like mini-melt style ice cream. The Dohmeyer Cryo Pelletizers deliver exceptional manufacturing flexibility through its modular architecture and precise control systems. The precision dosing module can be finely adjusted to handle liquids with varying densities, including lactobacilli cultures, emulsified proteins, and fruit-based syrups, guaranteeing accurate droplet formation across different recipes. Because the system is engineered for scalability, manufacturers can initially deploy the unit for small-batch clinical trials, and efficiently scale up to continuous, full-scale manufacturing without altering the core freezing dynamics, ensuring complete product consistency at any capacity.


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